OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as osteoporosis, rheumatoid arthritis, and osteosarcoma. Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Adipose tissues are the major source of OPN and also of its obesity-induced upregulation. Results: Serum BSP levels of MM-I patients was significantly higher than that of healthy controls (29.24 ± 5.57 vs. 20.89 ± 3.67, P = 0.001). 2010;37(2):123–36. However, analysis of chimera mice with competitive reconstitution of WT and IRF8-KO bone marrow cells as well as mice with IRF8 deficiency only in T cells indicated that IRF8 plays no intrinsic role in CTL activation. J Biol . COVID-19 is an emerging, rapidly evolving situation. Epub 2015 Jun 27. According to these results, another study conducted in healthy premenopausal women demonstrated that central adiposity was associated with low bone quality [37]. What is the player of the fat-bone axis in the bone marrow? An increment of marrow adipocytes was observed also by Schellinger et al. -, Denhardt DT, Giachelli CM, Rittling SR. Role of osteopontin in cellular signaling and toxicant injury. Adhesion of MC3T3-E1 cells to bone sialoprotein and bone osteopontin specifically bound to collagen I. OPN levels of MM-I patients were significantly lower than that of healthy individuals (12.03 ± 3.45 vs. 19.35 ± 4.67, P = 0.001). The primary role of OPN seems to facilitate recovery of the organism after injury or infection [38]. 2016;5(4) pii: E39. The Effect of an Enamel Matrix Derivative (Emdogain) Combined with Bone Ceramic on Bone Formation in Mandibular Defects: A Histomorphometric and Immunohistochemical Study in the Canine, The Scientific World Journal, 10.1100/2012 /196791, 2012, (1-9), (2012). OPN regulates various biological activities including matrix remodeling and tissue calcification, monocytes/macrophages migration and chemiotaxis, production of a variety of proinflammatory cytokines and chemokines, and inhibition of apoptosis activities [6]. Therefore, OPN could be a key regulator of inflammatory processes linked to obesity-induced adipose tissue inflammation and become a major target for treatment of adipose tissue inflammation-related disorders. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Some reports have shown that excessive visceral fat and fat mass have negative effects on bone health, being associated with low total bone mineral density and content [34–36]. OPN by itself induces expression of a variety of proinflammatory cytokines and chemokines being an important regulator for initiating adipose tissue macrophage and macrophage-like cells infiltration, triggering a vicious circle in which inflammatory cytokines play important roles in MSC differentiation. Bone extracellular matrix proteins osteopontin and osteonectin have important function during embryonic osteogenesis and are active in bone remodeling process. Studies have shown that OPN plays a role in bone metabolism and homeostasis. Originally described by Senger in 1979 as a secreted, 60-kDa transformation-specific phosphoprotein [8], human OPN is the most studied component of SIBLING family. After oophorectomy, rats showed an increase in the amount of fat in the bone marrow [17]. 2019 Mar;120:411-422. doi: 10.1016/j.bone.2018.12.001. Triggiani and colleagues [30], too, have observed similar results. Please enable it to take advantage of the complete set of features! Several roles have been ascribed to osteopontin in bone, many of which have the potential to impact material properties. Interestingly, an increase of OPN levels in serum and cerebrospinal fluid was found in Alzheimer’s disease (AD) patients [14]. In the study conducted by Inoue and Shinohara [3] on the effects of secreted OPN in regulating MSC differentiation, the authors revealed an important role of OPN-integrin in regulating adipogenic and osteogenic differentiation. [73]. β2M levels … Furthermore, OC levels were positively associated with cognitive performance in older nondemented women [53–56]. The authors declare that they have no competing interests. Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover. In addition, a direct role for Opn in HSC biology has now been identified. Review articles are excluded from this waiver policy. It is normally produced in bone, teeth, kidney and epithelial lining tissues and is found in plasma and breast milk. OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoclasts, and osteoblasts. Experimental evidence suggests that the gene of OPN is one of the most overexpressed genes in the adipose tissue of obese patients [1, 8]. • Spp1 is transiently expressed by cementoblasts and strongly expressed by alveolar bone osteoblasts during tooth development. Knowledge about bone extracellular matrix proteins explores the mechanisms of craniofacial development and helps to understand better morphopathogenesis of severe dentofacial anomalies. OPN, a multifunctional protein, is considered crucial for bone remodeling, biomineralization, and periodontal remodeling during mechanical tension and stress (orthodontic tooth movement). 2001;41(1):723–49. 2009;35(1–4):197–205. bone matrix proteins osteopontin and bone sialoprotein and the . Luo, “Transdifferentiation between bone and fat on bone metabolism,”, M. Esposito, F. P. Serpe, G. Diletti et al., “Serum levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in a population living in the Naples area, southern Italy,”, A. Viggiano, U. Nicodemo, E. Viggiano et al., “Mastication overload causes an increase in O2- production into the subnucleus oralis of the spinal trigeminal nucleus,”, B. Rinaldi, F. Guida, A. Furiano et al., “Effect of prolonged moderate exercise on the changes of nonneuronal cells in early myocardial infarction,”, G. Di Bernardo, G. Messina, S. Capasso et al., “Sera of overweight people promote in vitro adipocyte differentiation of bone marrow stromal cells,”. In spite of this, it is currently unknown whether OC and OPN alter bone morphology and consequently affect bone fracture resistance. Osteocalcin is a 49-amino acid bone matrix noncollagen protein produced by osteoblasts, which is involved in bone deposition and calcium homeostasis. These different forms can display specific expression and have distinct biological roles in different cell contexts. OPN is characterized by the presence of a polya... Osteopontin - J. Sodek, B. Ganss, M.D. A quantitative study of 84 iliac bone biopsies,”, C. Rozman, E. Feliu, L. Berga, J.-C. Reverter, C. Climent, and M.-J.  |  2013 Mar;28(3):688-99. doi: 10.1002/jbmr.1766. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The roles of the enzyme and the polymeric osteopontin are presently not fully understood. Carolina De Fusco, Antonietta Messina, Vincenzo Monda, Emanuela Viggiano, Fiorenzo Moscatelli, Anna Valenzano, Teresa Esposito, Chieffi Sergio, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina, "Osteopontin: Relation between Adipose Tissue and Bone Homeostasis", Stem Cells International, vol. Osteopontin: a bridge between bone and blood David N. Haylock1 and Susan K. Nilsson1,2 1Niche Laboratory, Australian Stem Cell Centre, Monash University, Clayton, Vic., Australia, and 2Department of Pathology, Melbourne University, Melbourne, Vic., Australia Summary The production of mature blood cells within the bone marrow (BM) is attributed to a pool of haemopoietic stem cells (HSC). The exact nature of factor that triggers this mechanisms is unknown. [78] in their study in vitro observed that the incubation of MSCs with the sera of overweight individuals promoted a bias in differentiating MSCs in adipogenic line, probably for a modification of circulating cytokines. To elucidate the function of OPN in bone metabolism, a cellular defect was created in parietal bone and tibia of 12 rats. Interestingly, Papakitsou et al. In this study, the influence of OPN o… As expected, the functions of OPN in the bone have become a research hotspot. 2017, Article ID 4045238, 6 pages, 2017. https://doi.org/10.1155/2017/4045238, 1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy, 2Department of Medicine, University of Padua, Padua, Italy, 3Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. However, in last decades the view that obesity has an protective effect against osteoporosis has been questioned [32, 33]. In Group 1, the left defects were filled with OPN-coated hydroxyapatite (OPN-H). The name “osteopontin” was chosen by Heinegard’s group that cloned the protein from the rat osteosarcoma. [38], in a cross-sectional study, evaluated 340 obese women and showed that trunk fat negatively correlated with BMD playing a detrimental role in skeletal metabolism in terms of low BMD, bone markers, and systemic factors influencing bone tissue. An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Bone sialoprotein (BSP), osteopontin (OPN), and β2-microglobulin (β2M) were measured with an enzyme-linked immunosorbent assay. [69] analyzed 81 iliac crest biopsies from elderly women and observed a considerable amount of fat in bone marrow of women with osteoporosis, relative to levels of fat in healthy young women. Osteopontin (OPN), also defined as secreted phosphoprotein-1 [1] (SPP1), sialoprotein-1 [1, 2], or early T lymphocyte activation 1 (Eta-1) [3] belongs to the small integrin-binding ligand N-linked glycoprotein (SIBLING) family [4]. Epub 2013 Sep 7. Studies have shown that OPN plays a role in bone metabolism and homeostasis. 2020 Jan 30;26:e919159 Authors: Si J, Wang C, Zhang D, Wang B, Zhou Y Abstract Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. Its overexpression in obese adipose tissue is mainly attributable to accumulation of the macrophages [1] and other inflammatory cells, stromal vascular cells, and adipocytes. Among cytokines, OPN may represent a multifaceted regulator between fat and bone on bone remodeling and contribute to the development of osteoporosis [3]. Different theories have been proposed to explain the complex interplay between adipose tissue and bone [16, 17]. In mouse models and obese humans, OPN is one of many inflammatory molecules overexpressed in adipose tissue [60, 61]. Body mass index (BMI) is generally recognized to have a good positive correlation with bone mineral density (BMD) as measured by central Dual-Energy X-Ray Absorptiometry (DXA) [21]. Carolina De Fusco and Antonietta Messina are first authors. Background Osteopontin (OPN) has been implicated in bone remodeling by activating the resorption process. HHS They are extensively and heterogeneously spliced, translated, phosphorylated, glycosylated, and proteolysed. Lee, J.-A. The relationship between obesity and skeleton is complex and not yet fully understood. Chailurkit, S. Chanprasertyothin, B. Hengprasith, P. Sritara, and B. Ongphiphadhanakul, “A reduced serum level of total osteocalcin in men predicts the development of diabetes in a long-term follow-up cohort,”, M. M. Oosterwerff, N. M. Van Schoor, P. Lips, and E. M. W. Eekhoff, “Osteocalcin as a predictor of the metabolic syndrome in older persons: a population-based study,”, K. B. D. S. Magalhães, M. M. Magalhães, E. T. Diniz, C. S. Lucena, L. Griz, and F. Bandeira, “Metabolic syndrome and central fat distribution are related to lower serum osteocalcin concentrations,”, Y. Bao, M. Xiaojing, R. Yang et al., “Inverse relationship between serum osteocalcin levels and visceral fat area in Chinese men,”, S. Bradburn, J. S. McPhee, L. Bagley et al., “Association between osteocalcin and cognitive performance in healthy older adults,”, S. Chieffi, A. Iavarone, A. Viggiano, M. Monda, and S. Carlomagno, “Effect of a visual distractor on line bisection,”, S. Chieffi, T. Iachini, A. Iavarone, G. Messina, A. Viggiano, and M. Monda, “Flanker interference effects in a line bisection task,”, A. Viggiano, S. Chieffi, D. Tafuri, G. Messina, M. Monda, and B. Genetic osteocalcin deletion induced glucose intolerance, increased fat mass, insulin resistance, decreased expression of insulin target genes in liver and muscle, and decreased adiponectin gene expression in adipose tissue. (1) There is an intimate link between adipocytes and osteoblasts related to their common origin from a progenitor cell, the pluripotential mesenchymal stem cell (MSCs) that resides in a specialized bone niche [41–43]. J Biomed Mater Res A. Osteopontin (OPN) is one of the major non-collagen proteins in extracellular bone matrix. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. We aimed to study the relationship between OPN, bone mineral density (BMD), bone turnover markers, vitamin D, and osteoporotic vertebral fractures in postmenopausal women. Osteopontin: Relation between Adipose Tissue and Bone Homeostasis, Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy, Department of Medicine, University of Padua, Padua, Italy, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy, F. W. Kiefer, M. Zeyda, J. Todoric et al., “Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations,”, Y. Wen, S. Jeong, Q. Xia, and X. Kong, “Role of osteopontin in liver diseases,”, M. Inoue and M. L. Shinohara, “Intracellular osteopontin (iOPN) and immunity,”, Q. Chen, P. Shou, L. Zhang et al., “An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells,”, K. A. Staines, V. E. MacRae, and C. Farquharson, “The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling,”, A. N. Kothari, M. L. Arffa, V. Chang et al., “Osteopontin—a master regulator of epithelial-mesenchymal transition,”, T. E. Kruger, A. H. Miller, A. K. Godwin, and J. Wang, “Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers,”, A. Oldberg, A. Franzen, and D. Heinegard, “Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence,”, J. Sodek, B. Ganss, and M. McKee, “Osteopontin,”, J. Chapman, P. D. Miles, J. M. Ofrecio et al., “Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice,”, F. W. Kiefer, S. Neschen, B. 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Trojano, “The improvement of cognitive functions is associated with a decrease of plasma Osteopontin levels in Natalizumab treated relapsing multiple sclerosis,”, S. Chieffi, M. Conson, and S. Carlomagno, “Movement velocity effects on kinaesthetic localisation of spatial positions,”, C. Poiana, M. Carsote, V. Radoi, A. Mihai, and C. Capatina, “Prevalent osteoporotic fractures in 622 obese and non- obese menopausal women,”, M. Monda, G. Messina, I. Scognamiglio et al., “Short-term diet and moderate exercise in young overweight men modulate cardiocyte and hepatocarcinoma survival by oxidative stress,”, E. A. Greco, A. Lenzi, and S. Migliaccio, “The obesity of bone,”, L. Guo, X. Yang, H. Zhu et al., “Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature,”, V. Monda, A. Valenzano, F. 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Valenzano et al., “Differences in corticospinal system activity and reaction response between karate athletes and non-athletes,”, S. Migliaccio, E. A. Greco, R. Fornari, L. M. Donini, and A. Lenzi, “Is obesity in women protective against osteoporosis?”, K. Zhu, M. Hunter, A. James, E. M. Lim, and J. P. Walsh, “Associations between body mass index, lean and fat body mass and bone mineral density in middle-aged Australians: the Busselton Healthy Ageing Study,”, M. Monda, G. Messina, C. Mangoni, and B. This observation was confirmed in subsequent studies [70–72]. Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. osteoclast integrin alpha v beta 3 potentiate bone resorption. J Bone Miner Res. Aim of the current study was to investigate an … USA.gov. While mineral and collagen have been investigated in greater detail, the contribution of noncollagenous proteins such as osteopontin to bone matrix material properties remains unclear. Recently, it has been shown that genetic OPN deficiency and antibody-mediated neutralisation in mice improve inflammation and protect from obesity and insulin resistance induced by a high-fat diet [46]. A. de Paula, and C. J. Rosen, “New insights into osteoporosis: the bone-fat connection,”, J. P. Rodrguez, L. Montecinos, S. Ros, P. Reyes, and J. Martnez, “Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation,”, I. Sekiya, B. L. Larson, J. T. Vuoristo, J.-G. Cui, and D. J. Prockop, “Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs),”, P. Meunier, J. Aaron, C. Edouard, and G. Vignon, “Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. 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